The Four'n Twenty pie was created in Bendigo, Victoria, Australia by Leslie Thompson McClure in 1947. Initially called the Dad & Dave Pie after the name of his cafe, McClure renamed the pie using the nursery rhyme suggestion from an employee. At that time, production was around 50 pies per day.
McClure took a sampling of his pies to the Royal Melbourne Agricultural Show, where they proved very popular. Increasing demand for the pie caused McClure to open a bakery in a pavilion of the showgrounds in 1949, then a factory in nearby Union Road, Ascot Vale in 1953, and eventually a larger factory in Kensington.
In 1960, McClure sold his stake in Four'n Twenty to the Victorian arm of Peters Ice Cream. Peters' subsequent owner, Pacific Dunlop, sold the brand to Simplot in 1995, and Simplot in turn sold Four'n Twenty and several other bakery brands to Patties Foods in 2003. Patties expanded their Bairnsdale manufacturing facility and consolidated Four'n Twenty production into it, closing the Kensington plant. The new plant can produce 21,000 pies per hour, 24 hours per day.
In 2006, the brand announced that the Four'n Twenty pie would be sold on the American market.
In 2017, to celebrate Four'n Twenty's 70th anniversary, the brand launched the Four'n Twenty Cheese and Vegemite Pie.
Later in 2017, Four'n Twenty launched the Topper, a crispy breaded pocket with lasagna, macaroni and cheese, or chicken cordon bleu fillings.
On April 21st 2019, Four'N Twenty launched its brand of meat pies in Japan, with a FourN Twenty Day celebration at the World Beer Museum in Tokyo.
In 2020, Four'n Twenty introduced a Vegan friendly meat-free pie to the market, said to have the same "taste, texture and flavour" as the original.